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KMID : 1038120180510030266
Clinical Endoscopy
2018 Volume.51 No. 3 p.266 ~ p.273
Characteristics of Synchronous and Metachronous Multiple Gastric Tumors after Endoscopic Submucosal Dissection of Early Gastric Neoplasm
Lee Hyun-Jik

Lee Yoo-Jin
Lee Ju-Yup
Kim Eun-Soo
Chung Woo-Jin
Jang Byoung-Kuk
Park Kyung-Sik
Hwang Jae-Seok
Cho Kwang-Bum
Abstract
Background/Aims: Endoscopic submucosal dissection (ESD) has been widely accepted as a method of treatment of early gastric tumor. This study aimed to identify the incidence and characteristics of multiple gastric tumors after ESD.

Methods: Patients with early gastric tumors who were treated by ESD from January 2004 to June 2012 and followed up with endoscopic examination periodically for at least 1 year were enrolled. All multiple gastric lesions were subsequently treated with ESD and the medical records of the patients were retrospectively reviewed.

Results: In total, 643 patients were included. The mean duration of endoscopic follow-up was 45.27¡¾27.59 (range, 12?148) months. Overall, 144 patients (22.4%) showed multiple gastric tumors during the follow-up period (44 synchronous [6.8%] and 100 metachronous [15.5%]). The cumulative incidence rate steadily increased during the follow-up period. More than 50% of the tumors that developed at the same longitudinal location of the stomach were of the same macroscopic and histological type as the primary lesions.

Conclusions: Because synchronous and/or metachronous gastric tumors are common, considerable attention should be paid to detect multiple gastric lesions after ESD of early gastric neoplasm.
KEYWORD
Stomach neoplasms, Endoscopic submucosal dissection, Neoplasms, second primary
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